FOXF2

Across TCGA patient cohorts, FOXF2 mutation is significantly associated with the RNA expression of many other genes, with 423 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXF2-associated genes across cancer lineages are RNA5SP232, RNU6-270P, and LIN28AP1. Each is linked with FOXF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXF2-to-partner and partner-to-FOXF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP232 grouped by FOXF2-low versus FOXF2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXF2→partner) and Y-score (partner→FOXF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP232 →	+0.299	+7.954	<.001	.008	3	2
LUAD	RNU6-270P →	+0.324	+5.924	<.001	<.001	3	2
LUAD	LIN28AP1 →	+0.055	+4.197	.007	.009	3	2
UCEC	TRAJ39 →	+0.772	+2.663	<.001	<.001	3	2
UCEC	RNU6-976P →	+0.353	+3.461	<.001	.003	3	2
COAD	RNU6-929P →	+0.368	+7.741	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 423 associations by consensus.

RNA5SP232 by FOXF2 expression — HNSC

Explore this box plot interactively →