FOXF2

Across TCGA patient cohorts, FOXF2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXF2-associated genes across cancer lineages are TIGAR, MEK1, and Notch1. Each is linked with FOXF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXF2-to-partner and partner-to-FOXF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by FOXF2-low versus FOXF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXF2→partner) and Y-score (partner→FOXF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.243	+2.486	<.001	.011	3	2
UCEC	MEK1 →	+0.351	+2.459	.046	.020	3	1
UCEC	Notch1 →	+0.207	+2.179	.002	.034	3	1
UCEC	p62 Lck ligand →	+0.323	+3.009	.040	.019	3	1
UCEC	PDCD4 →	-0.850	-3.169	<.001	.018	3	1
UCEC	Rb_pS807_S811 →	-0.401	-2.459	.040	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

TIGAR by FOXF2 expression — UCEC

Explore this box plot interactively →