FOXE1

Across TCGA patient cohorts, FOXE1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXE1-associated genes across cancer lineages are 4E-BP1, EGFR_pY1068, and Rictor_pT1135. Each is linked with FOXE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXE1-to-partner and partner-to-FOXE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by FOXE1-low versus FOXE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXE1→partner) and Y-score (partner→FOXE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.430	+3.489	<.001	.002	3	2
UCEC	EGFR_pY1068 →	-0.251	-2.115	.021	.019	3	2
UCEC	Rictor_pT1135 →	-0.130	-3.584	.003	.002	3	2
UCEC	C-Raf →	+0.219	+2.807	<.001	.003	3	2
UCEC	Di-Ras3 →	-0.219	-2.115	<.001	.019	3	2
COAD	eEF2 →	+0.403	+3.000	.005	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

4E-BP1 by FOXE1 expression — UCEC

Explore this box plot interactively →