FOXE1

Across TCGA cell cohorts, FOXE1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FOXE1-associated genes across cancer lineages are CFHR2, CLEC14A, and FOXS1. Each is linked with FOXE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXE1-to-partner and partner-to-FOXE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by FOXE1-low versus FOXE1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXE1→partner) and Y-score (partner→FOXE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CFHR2 →	+0.038	+4.022	<.001	.006	3	2
BLOOD_Leukemia	CLEC14A →	+2.628	+3.866	<.001	.001	3	1
BLOOD_Leukemia	FOXS1 →	+0.050	+3.212	.001	.002	3	1
BLOOD_Leukemia	OR52B6 →	+0.083	+3.847	<.001	.001	3	1
BLOOD_Leukemia	OPALIN →	+0.720	+3.762	<.001	.001	3	1
BLOOD_Leukemia	C14orf178 →	+0.203	+3.797	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

CFHR2 by FOXE1 expression — LARGE_INTESTINE

Explore this box plot interactively →