FOXD4L6

Across TCGA patient cohorts, FOXD4L6 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXD4L6-associated genes across cancer lineages are INPP4B, JNK_pT183_Y185, and MAPK_pT202_Y204. Each is linked with FOXD4L6 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXD4L6-to-partner and partner-to-FOXD4L6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by FOXD4L6-low versus FOXD4L6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXD4L6→partner) and Y-score (partner→FOXD4L6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.395	-3.000	.019	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.310	-3.308	<.001	.010	3	1
UCEC	MAPK_pT202_Y204 →	-0.551	-3.000	.025	.036	3	1
UCEC	STAT3_pY705 →	-0.644	-3.321	<.001	.010	3	1
UCEC	Cyclin-B1 →	+0.937	+3.321	.001	.010	3	1
UCEC	Cyclin-E2 →	+0.188	+2.817	.033	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

INPP4B by FOXD4L6 expression — UCEC

Explore this box plot interactively →