Across TCGA patient cohorts, FOXD4L1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXD4L1-associated genes across cancer lineages are GSK-3a-b_pS21_S9, Ku80, and MEK1. Each is linked with FOXD4L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXD4L1-to-partner and partner-to-FOXD4L1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXD4L1→partner) and Y-score (partner→FOXD4L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.346	+1.884	.039	.030	3	1
UCEC	Ku80 →	+0.236	+3.013	.011	.018	3	1
UCEC	MEK1 →	+0.310	+2.459	.031	.019	3	1
UCEC	MSH6 →	-0.392	-2.459	.002	.018	3	1
UCEC	Notch1 →	+0.153	+2.183	.005	.033	3	1
UCEC	p27_pT198 →	+0.086	+2.000	.040	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

FOXD4L1 survival (RNA) · tumor vs normal (RNA) · all FOXD4L1 data types