FOXD4

Across TCGA patient cohorts, FOXD4 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,118 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible FOXD4-associated GO terms across cancer lineages are Positive regulation of DNA repair, Nucleotide-excision repair, and Positive regulation of double-strand break repair via homologous recombination. Each is linked with FOXD4 in more than 20 cancer types. Because this analysis shows association rather than direction, both FOXD4-to-partner and partner-to-FOXD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by FOXD4-low versus FOXD4-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXD4→partner) and Y-score (partner→FOXD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Positive regulation of DNA repair →	+0.053	+0.719	<.001	<.001	3	21
SCLC	Nucleotide-excision repair →	+0.064	+0.668	<.001	<.001	3	20
SCLC	Positive regulation of double-strand break repair via homologous recombination →	+0.089	+0.880	.004	<.001	2	20
LAML	Negative regulation of DNA-templated transcription, elongation →	+0.038	+0.327	<.001	<.001	3	19
SCLC	Protein acylation →	+0.051	+0.699	.006	.005	2	20
LAML	Protein insertion into mitochondrial inner membrane →	+0.035	+0.354	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,118 associations by consensus.

Positive regulation of DNA repair by FOXD4 expression — SCLC

Explore this box plot interactively →