FOXD4

Across TCGA patient cohorts, FOXD4 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXD4-associated genes across cancer lineages are EGFR_pY1068, c-Kit, and A-Raf_pS299. Each is linked with FOXD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXD4-to-partner and partner-to-FOXD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by FOXD4-low versus FOXD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXD4→partner) and Y-score (partner→FOXD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.231	-2.000	.019	.030	3	2
UCEC	c-Kit →	-0.208	-2.000	.023	.010	3	2
UCEC	A-Raf_pS299 →	-0.171	-3.459	<.001	.005	3	1
UCEC	JNK2 →	+0.297	+2.000	<.001	.010	3	1
UCEC	Ku80 →	+0.255	+3.335	.006	.005	3	1
UCEC	MEK1 →	+0.327	+2.115	.023	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by FOXD4 expression — UCEC

Explore this box plot interactively →