FOXD4

Across TCGA cell cohorts, FOXD4 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOXD4-associated genes across cancer lineages are CALHM4, KRTAP3-2, and VAX1. Each is linked with FOXD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXD4-to-partner and partner-to-FOXD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CALHM4 grouped by FOXD4-low versus FOXD4-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXD4→partner) and Y-score (partner→FOXD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CALHM4 →	+0.375	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	KRTAP3-2 →	+0.062	+5.247	<.001	.001	3	1
LARGE_INTESTINE	VAX1 →	+0.523	+3.285	.005	.007	3	1
LARGE_INTESTINE	EN1 →	+1.292	+3.536	<.001	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.205	+2.688	.004	.008	3	1
LARGE_INTESTINE	CHSY3 →	+0.521	+3.252	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

CALHM4 by FOXD4 expression — BLOOD_Lymphoma

Explore this box plot interactively →