Across TCGA patient cohorts, FOXD3 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,747 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FOXD3-associated proteins across cancer lineages are RPRD2, MSH2, and MSH6. Each is linked with FOXD3 in more than 3 cancer types. Because this analysis shows association rather than direction, both FOXD3-to-partner and partner-to-FOXD3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXD3→partner) and Y-score (partner→FOXD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPRD2 →	+0.417	+0.563	<.001	<.001	3	4
GBM	MSH2 →	+0.416	+0.493	.001	.004	3	4
GBM	MSH6 →	+0.443	+0.519	.001	.002	3	4
HNSC	SP4_S46 →	+0.490	+0.432	.001	.006	3	3
GBM	ADAR →	+0.219	+0.672	<.001	<.001	3	3
GBM	CAST →	-0.372	-0.698	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,747 associations by consensus.

Exploration

FOXD3 survival (RNA) · tumor vs normal (RNA) · all FOXD3 data types