Across TCGA patient cohorts, FOXD3 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXD3-associated genes across cancer lineages are A-Raf_pS299, p62 Lck ligand, and PRAS40_pT246. Each is linked with FOXD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXD3-to-partner and partner-to-FOXD3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXD3→partner) and Y-score (partner→FOXD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.234	-3.169	<.001	.019	3	1
UCEC	p62 Lck ligand →	+0.484	+2.817	.004	.036	3	1
UCEC	PRAS40_pT246 →	+0.267	+2.183	.002	.035	3	1
UCEC	Rab25 →	-0.444	-3.321	.010	.010	3	1
UCEC	Annexin-1 →	+0.989	+2.189	<.001	.034	3	1
UCEC	SF2 →	-0.190	-2.990	<.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

FOXD3 survival (RNA) · tumor vs normal (RNA) · all FOXD3 data types