Across TCGA cell cohorts, FOXD3 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOXD3-associated genes across cancer lineages are OR1L6, C2orf80, and OR2T5. Each is linked with FOXD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXD3-to-partner and partner-to-FOXD3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXD3→partner) and Y-score (partner→FOXD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	OR1L6 →	+0.020	+5.169	<.001	.004	3	1
BONE	C2orf80 →	+0.126	+5.169	<.001	.004	3	1
BONE	OR2T5 →	+0.013	+5.169	<.001	.004	3	1
SKIN	FXYD4 →	+0.161	+4.977	<.001	.007	3	1
SKIN	OR13H1 →	+0.056	+4.977	<.001	.007	3	1
SKIN	OR6B3 →	+0.136	+6.022	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

FOXD3 survival (RNA) · tumor vs normal (RNA) · all FOXD3 data types