FOXD3-AS1

Across TCGA pan-cancer cohorts, FOXD3-AS1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated FOXD3-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher FOXD3-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FOXD3-AS1 expression acts as an unfavorable survival marker, although some lineages such as UVM and CESC show a favorable association.

KIRC, ACC, and THCA are the cancer types where FOXD3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	II,III,IV	0.435	0.629	<.001	158	view →
ACC	OS	Tertile	All	0.440	1.000	<.001	105	view →
THCA	DFS	Tertile	All	0.737	0.859	<.001	103	view →
COAD	DFS	Median	All	0.404	0.606	<.001	102	view →
UVM	DFS	Median	II,III,IV	0.773	0.413	<.001	81	view →
KICH	OS	Quartile	II,III,IV	0.182	0.884	<.001	73	view →
KIRP	OS	Tertile	All	0.503	0.779	<.001	59	view →
LGG	OS	Median	All	0.346	0.543	<.001	54	view →
MESO	DFS	Quartile	All	0.253	0.457	.008	37	view →
CESC	OS	Tertile	All	0.916	0.716	<.001	34	view →
UCEC	DFS	Quartile	All	0.754	0.884	<.001	32	view →
ESCA	DFS	Tertile	All	0.396	0.635	.004	28	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

FOXD3-AS1–KIRC (OS)

Open the KIRC breakdown →