Across TCGA patient cohorts, FOXD2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXD2-associated genes across cancer lineages are ACC_pS79, JNK_pT183_Y185, and S6_pS240_S244. Each is linked with FOXD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXD2-to-partner and partner-to-FOXD2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXD2→partner) and Y-score (partner→FOXD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.463	+2.459	.005	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.197	-2.446	.015	.020	3	1
UCEC	S6_pS240_S244 →	+0.620	+3.169	.001	.019	3	1
UCEC	STAT3_pY705 →	-0.381	-2.459	.002	.020	3	1
UCEC	Tuberin_pT1462 →	+0.232	+2.459	.038	.020	3	1
UCEC	Chk2_pT68 →	-0.187	-3.312	.038	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

FOXD2 survival (RNA) · tumor vs normal (RNA) · all FOXD2 data types