Across TCGA cell cohorts, FOXD2 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible FOXD2-associated genes across cancer lineages are APCS, IL36A, and OR2M5. Each is linked with FOXD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXD2-to-partner and partner-to-FOXD2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXD2→partner) and Y-score (partner→FOXD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	APCS →	+0.285	+4.643	<.001	.003	3	2
SOFT_TISSUE	IL36A →	+0.024	+4.930	.002	.008	3	1
SOFT_TISSUE	OR2M5 →	+0.019	+5.369	<.001	.004	3	1
SOFT_TISSUE	SMCP →	+0.136	+5.369	<.001	.004	3	1
SOFT_TISSUE	FCRL4 →	+0.013	+5.977	<.001	.001	3	1
SOFT_TISSUE	RPL10L →	+0.038	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

FOXD2 survival (RNA) · tumor vs normal (RNA) · all FOXD2 data types