FOXC2

Across TCGA patient cohorts, FOXC2 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,359 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FOXC2-associated proteins across cancer lineages are RAI14, FOXC2_S219, and RSU1. Each is linked with FOXC2 in more than 5 cancer types. Because this analysis shows association rather than direction, both FOXC2-to-partner and partner-to-FOXC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FOXC2 versus RAI14 in BRCA, with a Pearson correlation of 0.26.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXC2→partner) and Y-score (partner→FOXC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RAI14 →	+0.374	+0.548	<.001	<.001	3	6
PDAC	FOXC2_S219 →	+1.187	+1.391	<.001	<.001	3	6
BRCA	RSU1 →	+0.406	+0.624	<.001	<.001	3	6
BRCA	ASPN →	+0.960	+0.455	<.001	.001	3	6
CCRCC	CLEC3B →	+0.755	+0.925	<.001	<.001	3	6
GBM	IGFBP7 →	+0.720	+0.247	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,359 associations by consensus.

FOXC2 vs RAI14 — BRCA

Explore this scatter interactively →