FOXC2

Across TCGA patient cohorts, FOXC2 protein abundance is significantly associated with the RNA expression of many other genes, with 566 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible FOXC2-associated genes across cancer lineages are KLF5, RGCC, and FA2H. Each is linked with FOXC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXC2-to-partner and partner-to-FOXC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FOXC2 versus KLF5 in CCRCC, with a Pearson correlation of -0.69.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXC2→partner) and Y-score (partner→FOXC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KLF5 →	-1.558	-0.514	<.001	<.001	3	1
CCRCC	RGCC →	+1.833	+0.497	<.001	.001	3	1
CCRCC	FA2H →	-0.880	-0.480	.001	.002	3	1
CCRCC	KDELR1 →	-0.602	-0.514	.005	<.001	3	1
CCRCC	TGFBR1 →	-0.650	-0.514	.003	<.001	3	1
CCRCC	PPIF →	-1.497	-0.637	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 566 associations by consensus.

FOXC2 vs KLF5 — CCRCC

Explore this scatter interactively →