FOXC2

Across TCGA patient cohorts, FOXC2 mutation is significantly associated with the RNA expression of many other genes, with 610 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXC2-associated genes across cancer lineages are OR5F2P, MTND5P35, and PTH2. Each is linked with FOXC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FOXC2-to-partner and partner-to-FOXC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5F2P grouped by FOXC2-low versus FOXC2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXC2→partner) and Y-score (partner→FOXC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR5F2P →	+0.024	+4.302	<.001	.007	3	3
CESC	MTND5P35 →	+0.028	+5.539	<.001	.004	3	2
LUAD	PTH2 →	+0.516	+3.357	<.001	.007	3	2
LUAD	RNY1P7 →	+0.215	+4.444	<.001	.006	3	2
LUAD	MRPS31P1 →	+0.358	+4.554	<.001	.001	3	2
SKCM	MRPL50P4 →	+0.066	+4.098	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 610 associations by consensus.

OR5F2P by FOXC2 expression — SKCM

Explore this box plot interactively →