FOXC2

Across TCGA patient cohorts, FOXC2 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXC2-associated genes across cancer lineages are eIF4E, 4E-BP1, and FoxM1. Each is linked with FOXC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXC2-to-partner and partner-to-FOXC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by FOXC2-low versus FOXC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXC2→partner) and Y-score (partner→FOXC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.229	+3.169	.030	.019	3	2
UCEC	4E-BP1 →	+0.398	+3.029	.003	.018	3	2
UCEC	FoxM1 →	+0.356	+3.459	.006	.005	3	1
UCEC	GATA3 →	-0.241	-3.446	.011	.005	3	1
UCEC	Heregulin →	-0.185	-2.321	.002	.035	3	1
UCEC	Ku80 →	+0.264	+3.013	.026	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

eIF4E by FOXC2 expression — UCEC

Explore this box plot interactively →