FOXC2

Across TCGA cell cohorts, FOXC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,370 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FOXC2-associated GO terms across cancer lineages are Positive regulation of vascular wound healing, Regulation of heart rate by chemical signal, and Pyrimidine-containing compound transmembrane transport. Each is linked with FOXC2 in more than 10 cancer types. Because this analysis shows association rather than direction, both FOXC2-to-partner and partner-to-FOXC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of vascular wound healing grouped by FOXC2-low versus FOXC2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXC2→partner) and Y-score (partner→FOXC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of vascular wound healing →	-0.242	-1.901	.004	.009	2	11
BONE	Regulation of heart rate by chemical signal →	+0.450	+1.938	<.001	<.001	3	9
BONE	Pyrimidine-containing compound transmembrane transport →	-0.147	-1.949	.001	.004	2	10
UPPER_AERODIGESTIVE_TRACT	Regulation of plasminogen activation →	+0.161	+0.938	.002	.005	3	8
BREAST	Positive regulation of extracellular matrix organization →	+0.156	+1.310	<.001	.001	3	8
BONE	Coagulation →	+0.104	+1.800	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,370 associations by consensus.

Positive regulation of vascular wound healing by FOXC2 expression — LIVER

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