FOXC2

Across TCGA cell cohorts, FOXC2 mutation is significantly associated with the RNA expression of many other genes, with 549 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FOXC2-associated genes across cancer lineages are LRRC53, MBD3L2, and SSX7. Each is linked with FOXC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXC2-to-partner and partner-to-FOXC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC53 grouped by FOXC2-low versus FOXC2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXC2→partner) and Y-score (partner→FOXC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LRRC53 →	+0.007	+4.108	<.001	.005	3	1
OVARY	MBD3L2 →	+0.613	+4.029	<.001	.009	3	1
STOMACH	SSX7 →	+0.433	+5.285	<.001	.003	3	1
LUNG_NSCLC_LUAD	TEX55 →	+0.060	+3.770	<.001	.008	3	1
LARGE_INTESTINE	MCAT →	+0.655	+3.082	<.001	.007	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.539	+2.502	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 549 associations by consensus.

LRRC53 by FOXC2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →