FOXC2-AS1

Across TCGA pan-cancer cohorts, FOXC2-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated FOXC2-AS1 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher FOXC2-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FOXC2-AS1 expression acts as an unfavorable survival marker, although some lineages such as READ and KIRC show a favorable association.

BLCA, KICH, and MESO are the cancer types where FOXC2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.628	0.752	<.001	108	view →
KICH	DFS	Tertile	All	0.582	0.973	<.001	99	view →
MESO	OS	Tertile	All	0.240	0.453	<.001	95	view →
ACC	DFS	Median	All	0.176	0.588	<.001	74	view →
KIRP	DFS	Tertile	II,III,IV	0.494	0.770	.002	54	view →
STAD	OS	Quartile	II,III,IV	0.346	0.642	<.001	51	view →
HNSC	OS	Quartile	All	0.695	0.803	.007	45	view →
UVM	OS	Tertile	All	0.220	0.917	<.001	33	view →
READ	OS	Median	IV	0.940	0.475	.002	33	view →
SARC	DFS	Quartile	All	0.441	0.652	<.001	24	view →
LUAD	DFS	Tertile	All	0.218	0.427	.001	21	view →
PAAD	DFS	Quartile	All	0.301	0.616	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

FOXC2-AS1–BLCA (OS)

Open the BLCA breakdown →