FOXC1

Across TCGA patient cohorts, FOXC1 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,518 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible FOXC1-associated proteins across cancer lineages are FOXC1_S241, FOXC1_S235, and GLIPR2. Each is linked with FOXC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both FOXC1-to-partner and partner-to-FOXC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FOXC1 versus FOXC1_S241 in LSCC, with a Pearson correlation of 0.82.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXC1→partner) and Y-score (partner→FOXC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FOXC1_S241 →	+0.972	+1.064	<.001	<.001	3	6
UCEC	FOXC1_S235 →	+1.021	+1.532	<.001	<.001	3	5
BRCA	GLIPR2 →	+0.534	+1.402	<.001	<.001	3	5
OV	PRDX3 →	-0.455	-1.435	.001	<.001	3	4
CCRCC	PRELP →	+0.920	+0.802	<.001	<.001	3	4
COAD	RAI14 →	+0.352	+1.024	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,518 associations by consensus.

FOXC1 vs FOXC1_S241 — LSCC

Explore this scatter interactively →