FOXC1

Across TCGA patient cohorts, FOXC1 mutation is significantly associated with the RNA expression of many other genes, with 3,621 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXC1-associated genes across cancer lineages are OR7H2P, PNPLA3, and KIAA0586. Each is linked with FOXC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXC1-to-partner and partner-to-FOXC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7H2P grouped by FOXC1-low versus FOXC1-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXC1→partner) and Y-score (partner→FOXC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	OR7H2P →	+0.145	+5.878	<.001	.002	3	2
UCEC	PNPLA3 →	+0.783	+3.606	<.001	.001	3	2
UCEC	KIAA0586 →	+0.488	+3.764	<.001	<.001	3	2
UCEC	MTHFD1 →	+0.664	+2.180	<.001	.009	3	2
UCEC	USP14 →	+0.523	+2.831	.002	.001	3	2
COAD	CEP76 →	+0.554	+3.230	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,621 associations by consensus.

OR7H2P by FOXC1 expression — LIHC

Explore this box plot interactively →