FOXC1

Across TCGA patient cohorts, FOXC1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXC1-associated genes across cancer lineages are ERK2, JNK_pT183_Y185, and Ku80. Each is linked with FOXC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXC1-to-partner and partner-to-FOXC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by FOXC1-low versus FOXC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXC1→partner) and Y-score (partner→FOXC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.214	+2.222	.008	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.169	-1.687	.018	.044	3	1
UCEC	Ku80 →	+0.296	+1.713	.003	.027	3	1
UCEC	MAPK_pT202_Y204 →	-0.571	-3.308	.004	.009	3	1
UCEC	MEK1 →	+0.509	+3.700	.001	.001	2	2
UCEC	mTOR_pS2448 →	-0.191	-3.446	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ERK2 by FOXC1 expression — UCEC

Explore this box plot interactively →