FOXB1

Across TCGA patient cohorts, FOXB1 mutation is significantly associated with the RNA expression of many other genes, with 103 significant associations in total. COAD shows the largest number of these associations.

The most reproducible FOXB1-associated genes across cancer lineages are GAPDHP53, SUGT1P4, and RNU6-874P. Each is linked with FOXB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXB1-to-partner and partner-to-FOXB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDHP53 grouped by FOXB1-low versus FOXB1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXB1→partner) and Y-score (partner→FOXB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GAPDHP53 →	+0.061	+5.327	<.001	.002	3	2
LUAD	SUGT1P4 →	+0.244	+4.502	<.001	.007	3	2
COAD	RNU6-874P →	+2.014	+5.212	<.001	.007	3	2
COAD	RNU6ATAC29P →	+0.683	+6.392	<.001	.001	3	2
UCEC	RAB11AP2 →	+0.290	+7.049	<.001	<.001	3	2
SKCM	FAM197Y2 →	+0.116	+4.884	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 103 associations by consensus.

GAPDHP53 by FOXB1 expression — LUAD

Explore this box plot interactively →