FOXB1

Across TCGA cell cohorts, FOXB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,539 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FOXB1-associated GO terms across cancer lineages are Plasma membrane organization, Response to topologically incorrect protein, and Cellular response to topologically incorrect protein. Each is linked with FOXB1 in more than 6 cancer types. Because this analysis shows association rather than direction, both FOXB1-to-partner and partner-to-FOXB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Plasma membrane organization grouped by FOXB1-low versus FOXB1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXB1→partner) and Y-score (partner→FOXB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Plasma membrane organization →	+0.053	+0.489	.002	.008	3	7
UPPER_AERODIGESTIVE_TRACT	Response to topologically incorrect protein →	+0.064	+0.534	<.001	.003	3	6
UPPER_AERODIGESTIVE_TRACT	Cellular response to topologically incorrect protein →	+0.052	+0.525	.001	.004	3	6
BLOOD_Leukemia	Hormone-mediated signaling pathway →	+0.028	+0.819	<.001	.005	3	6
LUNG_NSCLC_LUAD	Mammary gland alveolus development →	-0.184	-0.883	<.001	<.001	3	6
LUNG_NSCLC_LUAD	Mammary gland lobule development →	-0.184	-0.883	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,539 associations by consensus.

Plasma membrane organization by FOXB1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →