FOXA3

Across TCGA patient cohorts, FOXA3 RNA expression is significantly associated with the protein abundance of many other proteins, with 8,970 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible FOXA3-associated proteins across cancer lineages are PLEKHA6_S777, QPCT, and MYH14. Each is linked with FOXA3 in more than 3 cancer types. Because this analysis shows association rather than direction, both FOXA3-to-partner and partner-to-FOXA3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FOXA3 versus PLEKHA6_S777 in PDAC, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXA3→partner) and Y-score (partner→FOXA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PLEKHA6_S777 →	+0.785	+0.776	<.001	<.001	3	4
LUAD	QPCT →	+0.646	+1.202	<.001	<.001	3	3
HNSC	MYH14 →	+0.651	+0.508	<.001	.002	3	3
HNSC	MYO5A →	-0.355	-0.513	<.001	.002	3	3
PDAC	MYO5A_S1652 →	-0.452	-0.989	<.001	<.001	3	3
HNSC	N4BP1 →	-0.313	-0.637	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,970 associations by consensus.

FOXA3 vs PLEKHA6_S777 — PDAC

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