FOXA3

Across TCGA patient cohorts, FOXA3 mutation is significantly associated with the RNA expression of many other genes, with 295 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXA3-associated genes across cancer lineages are MIR544A, RNU6-258P, and RNA5SP237. Each is linked with FOXA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXA3-to-partner and partner-to-FOXA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR544A grouped by FOXA3-low versus FOXA3-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXA3→partner) and Y-score (partner→FOXA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR544A →	+0.318	+7.954	<.001	.008	3	2
CESC	RNU6-258P →	+0.395	+7.164	<.001	<.001	3	2
CESC	RNA5SP237 →	+0.344	+5.669	<.001	.003	3	2
UCEC	SNORD114-18 →	+0.436	+3.299	<.001	.001	3	2
UCEC	LINC01635 →	+0.323	+3.202	.008	.009	3	2
COAD	RNU7-96P →	+1.108	+5.516	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 295 associations by consensus.

MIR544A by FOXA3 expression — HNSC

Explore this box plot interactively →