FOXA3

Across TCGA patient cohorts, FOXA3 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible FOXA3-associated genes across cancer lineages are p62 Lck ligand, Src, and PAI-1. Each is linked with FOXA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXA3-to-partner and partner-to-FOXA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by FOXA3-low versus FOXA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXA3→partner) and Y-score (partner→FOXA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.438	+2.817	.010	.036	3	1
UCEC	Src →	+0.248	+2.833	.021	.034	3	1
SKCM	PAI-1 →	+1.405	+3.017	<.001	.019	3	1
SKCM	PKC-a_pS657 →	-0.571	-3.000	.010	.036	3	1
SKCM	PKC-a →	-0.671	-3.000	.003	.036	3	1
SKCM	Cyclin-D1 →	+0.271	+3.000	.032	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

p62 Lck ligand by FOXA3 expression — UCEC

Explore this box plot interactively →