FOXA2

Across TCGA pan-cancer cohorts, FOXA2 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated FOXA2 data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher FOXA2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FOXA2 expression acts as an unfavorable survival marker.

THYM, HNSC, and DLBC are the cancer types where FOXA2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
HNSC	OS	Median	II,III,IV	0.176	0.674	<.001	39	view →
DLBC	DFS	Median	II,III,IV	0.065	0.829	<.001	24	view →
SCLC	DFS	Median	All	0.228	0.636	.008	18	view →
COAD	OS	Median	IV	0.082	0.659	<.001	18	view →
LIHC	DFS	Median	All	0.046	0.553	<.001	18	view →
SKCM	OS	Median	III,IV	0.221	0.706	<.001	15	view →
LUSC	OS	Median	All	0.320	0.679	.011	8	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

FOXA2–THYM (OS)

Open the THYM breakdown →