FOXA2

Across TCGA pan-cancer cohorts, FOXA2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FOXA2 data layer compared with 21 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher FOXA2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FOXA2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

UCEC, LSCC, and LUAD are the cancer types where FOXA2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.977	0.800	.020	8	view →
LSCC	DFS	Median	All	0.986	0.295	.002	5	view →
LUAD	DFS	Quartile	III,IV	0.132	0.800	.017	3	view →
PDAC	OS	Tertile	II,III,IV	0.463	0.234	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FOXA2–UCEC (DFS)

Open the UCEC breakdown →