FOXA1

Across TCGA pan-cancer cohorts, FOXA1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FOXA1 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher FOXA1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FOXA1 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

LUAD, PDAC, and LSCC are the cancer types where FOXA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.356	0.794	<.001	62	view →
PDAC	DFS	Median	III,IV	0.735	0.295	.008	9	view →
LSCC	OS	Median	II,III,IV	0.903	1.000	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FOXA1–LUAD (DFS)

Open the LUAD breakdown →