FOXA1

Across TCGA patient cohorts, FOXA1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOXA1-associated genes across cancer lineages are FOXO3a_pS318_S321, GAPDH, and PCNA. Each is linked with FOXA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXA1-to-partner and partner-to-FOXA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by FOXA1-low versus FOXA1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXA1→partner) and Y-score (partner→FOXA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FOXO3a_pS318_S321 →	-0.207	-2.994	<.001	.037	3	2
BRCA	GAPDH →	+0.943	+3.000	.002	.037	3	2
BRCA	PCNA →	+0.189	+2.822	.049	.036	3	2
BRCA	PRDX1 →	+0.257	+2.822	.023	.036	3	2
BRCA	S6_pS240_S244 →	+0.436	+3.321	.041	.011	3	2
UCEC	p62 Lck ligand →	+0.290	+1.331	.010	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

FOXO3a_pS318_S321 by FOXA1 expression — BRCA

Explore this box plot interactively →