FOXA1

Across TCGA cell cohorts, FOXA1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FOXA1-associated genes across cancer lineages are LRRC52, OR4N4, and MSGN1. Each is linked with FOXA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOXA1-to-partner and partner-to-FOXA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC52 grouped by FOXA1-low versus FOXA1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOXA1→partner) and Y-score (partner→FOXA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LRRC52 →	+0.032	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR4N4 →	+0.072	+4.930	<.001	.008	3	1
LARGE_INTESTINE	MSGN1 →	+0.061	+3.930	.007	.003	3	1
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	C12orf40 →	+0.011	+5.099	<.001	<.001	3	1
LARGE_INTESTINE	RBMY1J →	+0.008	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

LRRC52 by FOXA1 expression — SOFT_TISSUE

Explore this box plot interactively →