FOSL2

Across TCGA patient cohorts, FOSL2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOSL2-associated genes across cancer lineages are eEF2, p38-MAPK_pT180_Y182, and PDCD4. Each is linked with FOSL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOSL2-to-partner and partner-to-FOSL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by FOSL2-low versus FOSL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOSL2→partner) and Y-score (partner→FOSL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.414	+3.169	.035	.020	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.492	-3.156	.046	.020	3	1
UCEC	PDCD4 →	-0.605	-3.169	.019	.020	3	1
UCEC	4E-BP1_pT37_T46 →	-0.575	-2.986	.005	.035	3	1
UCEC	ATM →	-0.605	-3.169	.015	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

eEF2 by FOSL2 expression — UCEC

Explore this box plot interactively →