FOSL2

Across TCGA cell cohorts, FOSL2 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible FOSL2-associated genes across cancer lineages are CNGA2, GRM6, and AGXT2. Each is linked with FOSL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOSL2-to-partner and partner-to-FOSL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNGA2 grouped by FOSL2-low versus FOSL2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOSL2→partner) and Y-score (partner→FOSL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CNGA2 →	+0.099	+5.539	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	GRM6 →	+0.095	+3.510	<.001	.007	3	1
UPPER_AERODIGESTIVE_TRACT	AGXT2 →	+0.018	+4.321	<.001	<.001	3	1
UPPER_AERODIGESTIVE_TRACT	PRAMEF1 →	+0.106	+4.362	<.001	.001	3	1
UPPER_AERODIGESTIVE_TRACT	PRAMEF12 →	+0.099	+4.129	<.001	.002	3	1
UPPER_AERODIGESTIVE_TRACT	PRAMEF2 →	+0.116	+4.321	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

CNGA2 by FOSL2 expression — BLOOD_Leukemia

Explore this box plot interactively →