FOSL1

Across TCGA patient cohorts, FOSL1 mutation is significantly associated with the RNA expression of many other genes, with 501 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOSL1-associated genes across cancer lineages are GUF1, ATP2B2, and SLC45A3. Each is linked with FOSL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOSL1-to-partner and partner-to-FOSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUF1 grouped by FOSL1-low versus FOSL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOSL1→partner) and Y-score (partner→FOSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GUF1 →	+0.600	+3.346	<.001	.005	3	1
UCEC	ATP2B2 →	-0.882	-3.689	.006	.001	3	1
UCEC	SLC45A3 →	-0.657	-3.678	.003	.001	3	1
UCEC	CDA →	-1.160	-3.443	<.001	.005	3	1
UCEC	CPAMD8 →	-1.565	-3.678	<.001	.001	3	1
UCEC	DIP2A →	+0.520	+3.711	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 501 associations by consensus.

GUF1 by FOSL1 expression — UCEC

Explore this box plot interactively →