FOSL1

Across TCGA patient cohorts, FOSL1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOSL1-associated genes across cancer lineages are eEF2, ERK2, and GAPDH. Each is linked with FOSL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FOSL1-to-partner and partner-to-FOSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by FOSL1-low versus FOSL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOSL1→partner) and Y-score (partner→FOSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.402	+3.000	.020	.036	3	1
UCEC	ERK2 →	+0.189	+2.459	.042	.020	3	1
UCEC	GAPDH →	+0.623	+2.459	.016	.020	3	1
UCEC	GATA6 →	-0.169	-2.314	.029	.035	3	1
UCEC	Heregulin →	-0.161	-3.321	.006	.010	3	1
UCEC	ACVRL1 →	-0.220	-2.302	<.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

eEF2 by FOSL1 expression — UCEC

Explore this box plot interactively →