FOSB

Across TCGA pan-cancer cohorts, FOSB mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FOSB data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher FOSB mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FOSB expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where FOSB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.321	0.895	.036	15	view →
CCRCC	DFS	Median	III,IV	1.000	0.110	.024	9	view →
LSCC	DFS	Tertile	II,III,IV	0.811	1.000	.013	6	view →
PDAC	DFS	Median	All	0.164	0.765	.024	5	view →
GBM	OS	Median	All	0.948	0.723	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FOSB–LUAD (DFS)

Open the LUAD breakdown →