FOSB

Across TCGA patient cohorts, FOSB mutation is significantly associated with the RNA expression of many other genes, with 3,651 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOSB-associated genes across cancer lineages are MTCO3P10, LINC01487, and LAMTOR1. Each is linked with FOSB in more than 1 cancer types. Because this analysis shows association rather than direction, both FOSB-to-partner and partner-to-FOSB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCO3P10 grouped by FOSB-low versus FOSB-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOSB→partner) and Y-score (partner→FOSB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MTCO3P10 →	+0.366	+4.321	<.001	.002	3	2
CESC	LINC01487 →	+0.033	+3.595	<.001	.005	3	2
UCEC	LAMTOR1 →	+0.292	+2.732	.005	.003	3	2
UCEC	R3HCC1L →	+0.418	+2.828	<.001	.001	3	2
UCEC	TIGD2 →	+0.593	+2.686	<.001	<.001	3	2
UCEC	RNA5SP146 →	+0.227	+1.872	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,651 associations by consensus.

MTCO3P10 by FOSB expression — COAD

Explore this box plot interactively →