FOSB

Across TCGA patient cohorts, FOSB mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOSB-associated genes across cancer lineages are FoxM1, STAT3_pY705, and Tuberin. Each is linked with FOSB in more than 1 cancer types. Because this analysis shows association rather than direction, both FOSB-to-partner and partner-to-FOSB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by FOSB-low versus FOSB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOSB→partner) and Y-score (partner→FOSB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.218	+1.662	.017	.011	3	2
UCEC	STAT3_pY705 →	-0.420	-2.000	<.001	.003	3	2
UCEC	Tuberin →	+0.386	+2.321	<.001	.005	3	2
UCEC	eEF2 →	+0.252	+2.321	.046	.033	3	1
UCEC	eIF4E →	+0.224	+2.874	.002	<.001	3	1
UCEC	eIF4G →	+0.262	+2.459	.016	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

FoxM1 by FOSB expression — UCEC

Explore this box plot interactively →