FOS

Across TCGA pan-cancer cohorts, FOS mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FOS data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher FOS mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated FOS expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

LUAD, CCRCC, and GBM are the cancer types where FOS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.437	0.771	<.001	69	view →
CCRCC	DFS	Tertile	II,III,IV	0.963	0.293	.002	35	view →
GBM	DFS	Tertile	All	0.291	0.679	.027	4	view →
LSCC	DFS	Median	III,IV	0.900	0.508	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FOS–LUAD (OS)

Open the LUAD breakdown →