FOS

Across TCGA patient cohorts, FOS mutation is significantly associated with the RNA expression of many other genes, with 2,533 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOS-associated genes across cancer lineages are TPRKBP1, KRTAP4-9, and CRYBB2P1. Each is linked with FOS in more than 1 cancer types. Because this analysis shows association rather than direction, both FOS-to-partner and partner-to-FOS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TPRKBP1 grouped by FOS-low versus FOS-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOS→partner) and Y-score (partner→FOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TPRKBP1 →	+0.077	+3.145	<.001	.004	3	2
CESC	KRTAP4-9 →	+0.538	+5.103	<.001	.008	3	2
UCEC	CRYBB2P1 →	+0.572	+2.828	<.001	<.001	3	2
UCEC	CCDC134 →	+0.489	+2.700	.001	.006	3	2
UCEC	SGSM3 →	+0.425	+3.700	.002	.001	3	2
UCEC	TRMU →	+0.514	+3.839	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,533 associations by consensus.

TPRKBP1 by FOS expression — SKCM

Explore this box plot interactively →