FOS

Across TCGA patient cohorts, FOS mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOS-associated genes across cancer lineages are Cyclin-B1, 14-3-3_beta, and EGFR_pY1068. Each is linked with FOS in more than 1 cancer types. Because this analysis shows association rather than direction, both FOS-to-partner and partner-to-FOS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by FOS-low versus FOS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOS→partner) and Y-score (partner→FOS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.564	+2.087	.008	.005	3	2
UCEC	14-3-3_beta →	-0.083	-3.143	.031	.018	3	1
UCEC	EGFR_pY1068 →	-0.221	-2.087	.022	.005	3	1
UCEC	eIF4E →	+0.170	+2.459	.035	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.115	-3.575	.016	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.168	-2.584	.009	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Cyclin-B1 by FOS expression — UCEC

Explore this box plot interactively →