FOLH1

Across TCGA pan-cancer cohorts, FOLH1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FOLH1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FOLH1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FOLH1 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where FOLH1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FOLH1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+1.900	<.001	11	view →
KIRP	Male	All	−1.924	<.001	8	view →
KICH	All	II,III,IV	−1.475	<.001	8	view →
THCA	Male	All	+1.247	<.001	7	view →
BRCA	Female	All	−0.759	<.001	6	view →
COAD	Male	II,III,IV	+0.516	<.001	6	view →
CHOL	All	All	−2.063	<.001	5	view →
LUSC	All	All	+1.112	<.001	5	view →
BLCA	Male	All	+0.760	.008	5	view →
LUAD	All	All	+0.452	<.001	5	view →
LIHC	All	All	−0.750	<.001	3	view →
PRAD	All	All	+2.330	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

FOLH1–KIRC

Open the KIRC breakdown →