Across TCGA patient cohorts, FOCAD protein abundance is significantly associated with the RNA expression of many other genes, with 9,489 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FOCAD-associated genes across cancer lineages are MTAP, RGS4, and HACD4. Each is linked with FOCAD in more than 4 cancer types. Because this analysis shows association rather than direction, both FOCAD-to-partner and partner-to-FOCAD results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOCAD→partner) and Y-score (partner→FOCAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MTAP →	+0.874	+0.229	.003	<.001	3	5
BRCA	RGS4 →	+0.948	+0.249	.004	.002	3	4
HNSC	HACD4 →	+0.789	+0.294	<.001	<.001	3	4
LSCC	MLH3 →	-0.501	-0.401	<.001	<.001	3	4
COAD	BCAS4 →	-0.640	-0.140	.001	.005	3	3
UCEC	AVEN →	+0.710	+0.272	.002	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,489 associations by consensus.

Exploration

FOCAD survival (RNA) · tumor vs normal (RNA) · all FOCAD data types