Across TCGA patient cohorts, FOCAD mutation is significantly associated with the RNA expression of many other genes, with 3,527 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FOCAD-associated genes across cancer lineages are RPL23AP82, SNRPEP7, and PPIL2. Each is linked with FOCAD in more than 3 cancer types. Because this analysis shows association rather than direction, both FOCAD-to-partner and partner-to-FOCAD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FOCAD→partner) and Y-score (partner→FOCAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPL23AP82 →	+0.378	+1.595	<.001	<.001	3	4
KIRP	SNRPEP7 →	+0.173	+4.967	<.001	.009	3	3
UCEC	PPIL2 →	+0.304	+2.123	<.001	<.001	3	3
UCEC	ESS2 →	+0.260	+1.595	<.001	<.001	3	3
UCEC	GRPEL1 →	+0.354	+1.584	<.001	<.001	3	3
UCEC	DHDDS →	+0.327	+1.740	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,527 associations by consensus.

Exploration

FOCAD survival (RNA) · tumor vs normal (RNA) · all FOCAD data types