FNTB

Across TCGA patient cohorts, FNTB mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FNTB-associated genes across cancer lineages are Chk2, EGFR_pY1068, and INPP4B. Each is linked with FNTB in more than 1 cancer types. Because this analysis shows association rather than direction, both FNTB-to-partner and partner-to-FNTB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk2 grouped by FNTB-low versus FNTB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FNTB→partner) and Y-score (partner→FNTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Chk2 →	-0.217	-2.321	.034	.034	3	2
UCEC	EGFR_pY1068 →	-0.296	-2.115	.006	.019	3	1
UCEC	INPP4B →	-0.332	-2.321	.018	.034	3	1
UCEC	Ku80 →	+0.210	+1.598	.042	.044	3	1
UCEC	p27_pT198 →	+0.129	+3.169	.005	.019	3	1
UCEC	S6_pS240_S244 →	+0.394	+2.321	.026	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Chk2 by FNTB expression — UCEC

Explore this box plot interactively →