FNTB

Across TCGA cell cohorts, FNTB mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FNTB-associated genes across cancer lineages are HSFY2, HSFY1, and KRTAP6-1. Each is linked with FNTB in more than 1 cancer types. Because this analysis shows association rather than direction, both FNTB-to-partner and partner-to-FNTB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSFY2 grouped by FNTB-low versus FNTB-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FNTB→partner) and Y-score (partner→FNTB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HSFY2 →	+0.015	+5.643	.002	.002	3	1
BLOOD_Lymphoma	HSFY1 →	+0.015	+5.209	.003	.005	3	1
BLOOD_Lymphoma	KRTAP6-1 →	+0.090	+5.209	<.001	.005	3	1
LARGE_INTESTINE	MAGEB4 →	+0.022	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CRISP1 →	+0.014	+4.415	<.001	.007	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

HSFY2 by FNTB expression — BLOOD_Lymphoma

Explore this box plot interactively →